Routine Clinical Chemistry
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Chemistry Reagents & Calibrators
AV-Creatinine 240 Kinetic Enzymatic Creatinine Reagent
Liquid enzymatic creatinine reagent (creatininase / creatinase / sarcosine oxidase method) in 4 × 60 mL format. Improved rejection of common interferences and extended onboard stability. Designed by Aurevant Medical for accurate, specific creatinine measurement on automated and semi-automated clinical chemistry analyzers.
No approved datasheet is available for this product yet.
Product Overview
Overview
The Aurevant AV-Creatinine 240 is a liquid, ready-to-use enzymatic reagent for the quantitative determination of creatinine in human serum, plasma and urine. It utilizes a multi-enzyme cascade (creatininase, creatinase and sarcosine oxidase) coupled to a peroxidase detection system, providing high specificity and significantly reduced interference from non-creatinine chromogens compared with traditional Jaffe methods.
Supplied in a practical 4 × 60 mL pack, the reagent is formulated for reliable performance on both fully automated and semi-automated systems. It offers good onboard stability, a wide measuring range and excellent precision, making it suitable for routine renal function testing, eGFR calculation support and STAT creatinine requests.
The reagent is optimized for use on Aurevant AV-Chem series analyzers and is also compatible with other open-system clinical chemistry instruments that support enzymatic creatinine methods. Improved interference rejection from bilirubin, hemolysis and certain drugs enhances result reliability in challenging samples.
This product is an original Aurevant Medical reagent manufactured under controlled conditions and intended for professional laboratory use by trained personnel.
Supplied in a practical 4 × 60 mL pack, the reagent is formulated for reliable performance on both fully automated and semi-automated systems. It offers good onboard stability, a wide measuring range and excellent precision, making it suitable for routine renal function testing, eGFR calculation support and STAT creatinine requests.
The reagent is optimized for use on Aurevant AV-Chem series analyzers and is also compatible with other open-system clinical chemistry instruments that support enzymatic creatinine methods. Improved interference rejection from bilirubin, hemolysis and certain drugs enhances result reliability in challenging samples.
This product is an original Aurevant Medical reagent manufactured under controlled conditions and intended for professional laboratory use by trained personnel.
Product name and code identify the record only; they are not a substitute for current product documentation. Confirm intended use, configuration, availability, supported applications, and all technical and commercial terms in writing before procurement.
Key Features
Features
- •Enzymatic method with high specificity for creatinine
- •Significantly reduced interference from non-creatinine chromogens versus traditional Jaffe methods
- •Liquid ready-to-use format – minimal preparation required
- •Extended onboard stability of up to 28 days on refrigerated systems
- •Wide measuring range covering normal and highly elevated creatinine levels
- •Excellent precision suitable for eGFR calculation support
- •Optimized applications available for Aurevant AV-Chem series analyzers
- •Compatible with other open-system clinical chemistry instruments
- •Convenient 4 × 60 mL pack size
- •Clear package insert with detailed performance data and interference studies
Key advantages
- •Enzymatic cascade provides higher analytical specificity than alkaline picrate (Jaffe) methods
- •Reduced interference from bilirubin, hemoglobin and certain drugs improves result reliability in complex samples
- •Liquid format eliminates reconstitution variability and saves preparation time
- •Good onboard stability reduces reagent waste and bottle-change frequency
- •Wide dynamic range allows measurement of both normal and highly elevated creatinine concentrations without excessive dilution
- •Fully compatible with the Aurevant AV-Chem analyzer family and other open systems
Sample Types
- →Serum
- →Plasma (lithium heparin or EDTA)
- →Urine (appropriately diluted)
Safety
Safety Information
For in-vitro diagnostic use only. Not for therapeutic use in humans or animals. Handle all patient samples as potentially infectious. Wear appropriate personal protective equipment (gloves, lab coat, eye protection). Avoid contact with skin and eyes; in case of contact, rinse thoroughly with water. Store at 2–8 °C; do not freeze. Do not use after the expiry date printed on the label. Dispose of reagent and contaminated materials in accordance with local laboratory and environmental regulations. Consult the full package insert and Safety Data Sheet (SDS) before use.
Instructions
Directions for Use
Remove the reagent bottles from refrigerated storage (2–8 °C) and allow them to equilibrate to the temperature required by the analyzer application if necessary.
Technical Data
Specifications
Specifications
Research Status
proposed_unverified_concept
Publication Approval
approved_for_publication
Technical Specification Status
verified_against_current_product_documentation
Publication Status
inactive_pending_review
Specifications Status
not_provided
Note
Optional verification metadata; product publication does not require any fields beyond product name and model.
Use Cases
Applications
- →Routine serum and plasma creatinine measurement
- →Urine creatinine determination (quantitative)
- →Renal function testing and monitoring
- →Support for eGFR calculation
- →STAT / emergency creatinine testing
- →Use on fully automated and semi-automated clinical chemistry analyzers
Renal Function Testing
Clinical chemistry applications supporting the laboratory assessment of kidney function.
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Product questions
Frequently Asked Questions
What method does the AV-Creatinine 240 use?
It uses a multi-enzyme enzymatic method (creatininase / creatinase / sarcosine oxidase) coupled to a peroxidase colorimetric detection system. This provides higher specificity than traditional Jaffe methods.
Is the reagent ready to use?
Yes. It is supplied as a liquid ready-to-use reagent. No reconstitution is required.
What is the onboard stability?
On a refrigerated analyzer (2–8 °C) the reagent typically remains stable for up to 28 days. Exact claims are stated in the package insert.
Does this method have better interference rejection than Jaffe?
Yes. The enzymatic method shows significantly reduced interference from bilirubin, hemoglobin and certain non-creatinine chromogens compared with conventional alkaline picrate (Jaffe) methods.
Which sample types are validated?
Serum, plasma (heparin or EDTA) and urine (after appropriate dilution) are validated sample types.
Can the reagent be used on non-Aurevant analyzers?
Yes, on open-system analyzers after the laboratory has validated the application parameters. Aurevant Medical provides optimized applications for its own AV-Chem series.
Is this reagent suitable for eGFR calculation?
Yes. When used with appropriate calibrators and laboratory-validated equations (e.g., CKD-EPI), the results support estimated glomerular filtration rate reporting.
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